The driver of the truck is believed to have ploughed down a bicycle path on the West Side Highway, mowing down cyclists before coming to a stop.
6 people are confirmed dead with 15 others injured.
Josh Groban tweeted after hearing ‘gunshots’: ‘Oh my god I just heard gunshots and ran with my dog. Downtown. F***,’.
An eyewitness told US media he heard about nine or 10 shots, but could not identify which direction they were coming from.
The FBI has joined the New York City Police Department in investigating the incident and President Trump has been briefed.
At least one police officer has been shot.
Disturbing video footage from the scene shows at least two people lying face down and motionless on the popular cycle path.
One witness told News 4: “A guy got out with his biker jacket and started shooting up the place.
“All the kids were in the courtyard at P.S. 89 and started running.
“Then I saw the bus over there, all the kids went into this building. I went to go help the driver of this special ed bus, it looks like.
“I wasn’t sure why he was so spaced out and then I went to the other side, it was all caved on. A poor girl was stuck right above the wheel well. There were two kids that were just stuck by the window. It was all blown out.”
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